Onchocerciasis-Associated Epilepsy
Cross-source consensus on Onchocerciasis-Associated Epilepsy from 1 sources and 7 claims.
1 sources · 7 claims
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Highlighted claims
- The causal mechanism linking onchocerciasis to epilepsy has not been established. — Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures: a pilot study in Aketi, Democratic Republic of the Congo
- OAE usually appears in previously healthy children aged 3–18 years, with peak onset between ages 8 and 11. — Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures: a pilot study in Aketi, Democratic Republic of the Congo
- The clinical spectrum of OAE includes generalised tonic-clonic seizures, absence seizures, and nodding seizures. — Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures: a pilot study in Aketi, Democratic Republic of the Congo
- OAE may also present as Nakalanga syndrome, characterised by growth retardation, physical deformities, endocrine dysfunction, and mental impairment. — Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures: a pilot study in Aketi, Democratic Republic of the Congo
- OAE clusters in particular families and villages in onchocerciasis-endemic areas near blackfly-infested rivers. — Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures: a pilot study in Aketi, Democratic Republic of the Congo
- Successful onchocerciasis elimination programmes are associated with reduced OAE prevalence. — Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures: a pilot study in Aketi, Democratic Republic of the Congo
- Proposed pathogenic mechanisms of OAE include direct CNS invasion by microfilariae, passage of excretory-secretory products across the blood-brain barrier, Wolbachia involvement, and immune-triggered neurological injury. — Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures: a pilot study in Aketi, Democratic Republic of the Congo