Opioid Exposure

Benefits

Risks & contraindications

Evidence quality

Highlighted claims

• The trial is designed to test whether IOC2-guided titration can reduce opioid exposure while maintaining adequate pain control. — Effect of the index of consciousness 2 on intraoperative opioid dosage in ovarian cancer patients receiving neoadjuvant chemotherapy: a study protocol for a randomised controlled trial
• High-dose or long-term opioid use is associated with immunosuppressive effects involving natural killer cells and interleukin-1 beta production. — Effect of the index of consciousness 2 on intraoperative opioid dosage in ovarian cancer patients receiving neoadjuvant chemotherapy: a study protocol for a randomised controlled trial
• Excessive opioid administration may worsen postoperative pain, complications, recovery quality, or immune function. — Effect of the index of consciousness 2 on intraoperative opioid dosage in ovarian cancer patients receiving neoadjuvant chemotherapy: a study protocol for a randomised controlled trial
• Lower-opioid analgesia may help avoid immunosuppressive effects in patients whose immune function is compromised by cancer and chemotherapy. — Effect of the index of consciousness 2 on intraoperative opioid dosage in ovarian cancer patients receiving neoadjuvant chemotherapy: a study protocol for a randomised controlled trial
• The protocol cites evidence that opioid-free anaesthesia improved postoperative quality of life compared with standard anaesthesia, while noting that this trial does not test opioid-free anaesthesia. — Effect of the index of consciousness 2 on intraoperative opioid dosage in ovarian cancer patients receiving neoadjuvant chemotherapy: a study protocol for a randomised controlled trial