Oral Anticoagulation

How it works

Benefits

Dosage & preparation

Risks & contraindications

Evidence quality

Highlighted claims

• Oral anticoagulation prevents ischemic stroke in patients with atrial fibrillation and is guideline-recommended for AF patients at thromboembolic risk. — Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in large- or small-vessel disease ischaemic stroke in the USA
• In the model, patients switched from aspirin to a direct oral anticoagulant after atrial fibrillation was detected unless prior bleeding precluded it. — Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in large- or small-vessel disease ischaemic stroke in the USA
• The base case assumed complete OAC uptake after atrial fibrillation detection, while scenarios tested lower uptake rates of 90% and 76%. — Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in large- or small-vessel disease ischaemic stroke in the USA
• Patients who had hemorrhagic stroke while taking OAC were permanently switched to aspirin in the model. — Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in large- or small-vessel disease ischaemic stroke in the USA
• OAC uptake in practice may be lower than the base-case assumption because of refusal, contraindications, bleeding complications, and follow-up deviations. — Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in large- or small-vessel disease ischaemic stroke in the USA
• Evidence from related trials suggests probable benefit of DOACs for device-detected subclinical atrial fibrillation after stroke, but definitive evidence in the LAD/SVD subgroup is lacking. — Cost-effectiveness of an insertable cardiac monitor to detect atrial fibrillation in large- or small-vessel disease ischaemic stroke in the USA