Oxaliplatin-Induced Peripheral Neuropathy

How it works

Risks & contraindications

Evidence quality

Highlighted claims

• Oxaliplatin-induced peripheral neuropathy occurs in a dose-dependent manner and is the drug's major limiting toxicity. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
• Chronic OIPN can substantially impair daily life and may force chemotherapy modification or discontinuation because it correlates with cumulative oxaliplatin exposure. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
• No drug or medical device currently has strong evidence for preventing OIPN. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
• Acute OIPN symptoms such as cold dysesthesia and muscle cramps are typically transient and resolve within a few days. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
• Agents such as vitamin B12, calcium-magnesium preparations, gabapentin, pregabalin, and goshajinkigan are sometimes used empirically but have insufficient efficacy evidence. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial
• Chronic OIPN may become irreversible once established, making prevention especially important. — Possible preventive effect of surgical glove compression therapy on oxaliplatin-induced peripheral neuropathy: study protocol of a multicentre, phase II/III, randomised controlled trial–the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO)-12 trial