PATHFAST TB LAM Ag Assay
Cross-source consensus on PATHFAST TB LAM Ag Assay from 1 sources and 6 claims.
1 sources · 6 claims
How it works
Preparation
Comparisons
Evidence quality
Highlighted claims
- The PATHFAST TB LAM Ag assay is a fully automated, cartridge-based chemiluminescent enzyme immunoassay that quantifies sputum LAM within one hour with minimal manual handling. — Evaluating the PATHFAST TB LAM Ag assay as a treatment monitoring tool for pulmonary tuberculosis: protocol for a prospective longitudinal study in Nairobi, Kenya
- All prior PATHFAST-LAM findings were based on retrospective analyses of stored samples, leaving the clinical utility for predicting treatment failure unvalidated prospectively. — Evaluating the PATHFAST TB LAM Ag assay as a treatment monitoring tool for pulmonary tuberculosis: protocol for a prospective longitudinal study in Nairobi, Kenya
- PATHFAST-LAM testing is performed on both raw sputum and NALC–NaOH processed sputum to evaluate the assay across different laboratory settings. — Evaluating the PATHFAST TB LAM Ag assay as a treatment monitoring tool for pulmonary tuberculosis: protocol for a prospective longitudinal study in Nairobi, Kenya
- The LAM extraction procedure involves NaOH treatment, heat at 100°C, neutralisation, and centrifugation, with a total extraction time of approximately 30 minutes. — Evaluating the PATHFAST TB LAM Ag assay as a treatment monitoring tool for pulmonary tuberculosis: protocol for a prospective longitudinal study in Nairobi, Kenya
- Studies from Kenya and South Africa confirmed that sputum LAM concentrations measured by PATHFAST-LAM correlate with culture-based bacterial load. — Evaluating the PATHFAST TB LAM Ag assay as a treatment monitoring tool for pulmonary tuberculosis: protocol for a prospective longitudinal study in Nairobi, Kenya
- Previous studies found no significant difference in LAM concentrations between raw and NALC–NaOH processed sputum, though supporting data are limited. — Evaluating the PATHFAST TB LAM Ag assay as a treatment monitoring tool for pulmonary tuberculosis: protocol for a prospective longitudinal study in Nairobi, Kenya