Pharmacodynamic Targets

Cross-source consensus on Pharmacodynamic Targets from 1 sources and 4 claims.

1 sources · 4 claims

How it works

Beta-lactam effectiveness depends on the time free antibiotic concentration remains above the pathogen MIC. — Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population
The KLOX-SAB efficacy target is unbound cloxacillin above 0.5 mg/L for the full dosing interval. — Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population
For severe infections, the recommended beta-lactam target is 100% fT>MIC. — Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population
Overexposure is defined as unbound concentration above 5 mg/L or total concentration above 50 mg/L. — Unbound cloxacillin plasma concentrations in relation to toxicity and renal function: protocol for a prospective, observational clinical trial in a real-world Staphylococcus aureus bacteraemia population