Plasma Classifier Development

How it works

Comparisons

Evidence quality

Other

Highlighted claims

• Discovery-based plasma proteomic profiling is performed within the discovery cohort. — Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression
• Candidate clinical variables, patient-reported outcomes, and protein markers are first screened using univariate logistic regression. — Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression
• Elastic net modelling selects a stable, parsimonious predictor set while controlling for overfitting. — Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression
• Clinical-only, protein-only, and combined models are compared by ROC/AUC. — Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression
• Internally validated models are tested in an independent validation cohort using targeted mass spectrometry. — Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression