Plasma Exchange in ANCA-Associated Vasculitis

How it works

Risks & contraindications

Comparisons

Highlighted claims

• The guideline panel considered the key benefit of plasma exchange to be reduced end-stage kidney disease and the key harm to be increased serious infections. — Development of an educational video to support guideline panels in incorporating patient values and preferences into recommendation-making: qualitative one-on-one interviews and brainstorming meetings
• The absolute balance of benefit and harm from plasma exchange varied by patients' baseline risk of end-stage kidney disease, represented by serum creatinine levels. — Development of an educational video to support guideline panels in incorporating patient values and preferences into recommendation-making: qualitative one-on-one interviews and brainstorming meetings
• For patients with serum creatinine of 200 micromol/L or lower, plasma exchange was estimated to reduce end-stage kidney disease by 4 per 1000 patients but increase serious infections by 27 per 1000 patients. — Development of an educational video to support guideline panels in incorporating patient values and preferences into recommendation-making: qualitative one-on-one interviews and brainstorming meetings
• The panel ultimately inferred that most, all, or almost all patients with serum creatinine of 300 micromol/L or lower would decline plasma exchange, while patients with serum creatinine above 300 micromol/L would choose it. — Development of an educational video to support guideline panels in incorporating patient values and preferences into recommendation-making: qualitative one-on-one interviews and brainstorming meetings