Pneumococcal Conjugate Vaccine

Benefits

Risks & contraindications

Evidence quality

Other

Highlighted claims

• Six studies examined PCV against laboratory-confirmed viral or bacterial hospitalisations. — Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children
• PCV was included only for pathogen-confirmed outcomes to reduce confounding from non-specific clinical diagnoses. — Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children
• The largest reported single protective PCV effect was against influenza hospitalisation in fully vaccinated Spanish children during the pandemic wave. — Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children
• Most PCV studies reported beneficial or neutral effects. — Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children
• Some negative PCV associations were observed for adenovirus-confirmed hospitalisations in children older than 12 months. — Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children
• Existing vaccines including PCV may provide a cost-effective RSV prevention strategy where RSV-specific immunisation is unavailable. — Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children