PPI Deprescribing Strategies

Dosage & preparation

Preparation

Comparisons

Highlighted claims

• The trial compares on-demand PPI, alginate replacement and fixed taper strategies over an initial 1-month deprescription period. — Primary carE PPi dEprescRibing (PEPPER) trial: a protocol for determining the optimal strategy for stopping chronic proton pump inhibitor therapy in primary care patients
• Current guidance generally recommends dose reduction before stopping PPIs. — Primary carE PPi dEprescRibing (PEPPER) trial: a protocol for determining the optimal strategy for stopping chronic proton pump inhibitor therapy in primary care patients
• After completing the allocated strategy, patients are asked to stop PPI or alginate use completely for 1 month with rescue antacids only. — Primary carE PPi dEprescRibing (PEPPER) trial: a protocol for determining the optimal strategy for stopping chronic proton pump inhibitor therapy in primary care patients
• The fixed taper arm is the comparator because Belgian guidelines recommend gradual reduction and feasibility work found it common among GPs. — Primary carE PPi dEprescRibing (PEPPER) trial: a protocol for determining the optimal strategy for stopping chronic proton pump inhibitor therapy in primary care patients
• Antacids, alginates or H2-receptor antagonists may be used to limit symptom recurrence, but H2-receptor antagonists are unavailable in Belgium for this trial. — Primary carE PPi dEprescRibing (PEPPER) trial: a protocol for determining the optimal strategy for stopping chronic proton pump inhibitor therapy in primary care patients