Predisposition Genes
Cross-source consensus on Predisposition Genes from 1 sources and 5 claims.
1 sources · 5 claims
How it works
Risks & contraindications
Comparisons
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Highlighted claims
- RB1 showed the highest penetrance for retinoblastoma among dominantly inherited genes in the study. — Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing
- NF1 was the most common predisposition gene among all tumour cases in the cohort. — Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing
- WT1 showed lower penetrance for Wilms tumour than RB1 did for retinoblastoma. — Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing
- WT1-associated Wilms tumours in the follow-up group arose from truncating variants. — Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing
- The gene spectrum in this cohort emphasized organ-specific and developmental syndrome genes rather than the DNA repair genes often seen in prior pediatric cancer cohorts. — Pathogenic germline variations and cancer risks in pediatric patients referred for genetic testing