Procalcitonin Kinetics

Cross-source consensus on Procalcitonin Kinetics from 1 sources and 6 claims.

1 sources · 6 claims

Uses

How it works

Benefits

Evidence quality

Highlighted claims

KIPRUN applies procalcitonin kinetics to antibiotic initiation rather than antibiotic discontinuation. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
The approximately twofold PCT increase approach has not previously been tested in a randomized controlled trial. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
Observational studies suggest that about a twofold PCT increase predicts infection with a mean area under the curve of 0.85. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
Using an 80-90% decline from peak PCT values can reduce antibiotic treatment duration by a median of 2 days and may provide mortality benefit. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
An early rise in PCT over a defined period may indicate a new ICU infection. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
The MOSES study showed prognostic value for PCT kinetics. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients