Procalcitonin Thresholds

Cross-source consensus on Procalcitonin Thresholds from 1 sources and 6 claims.

1 sources · 6 claims

How it works

Risks & contraindications

Evidence quality

Highlighted claims

A fixed PCT value can rise after non-infectious insults, including trauma and sterile inflammation. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
A fixed PCT threshold is limited because PCT reflects host response, which varies between patients. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
Current 2021 sepsis guidance weakly recommends against using procalcitonin to initiate antibiotics because evidence certainty is very low. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
Treating isolated PCT values such as 0.5 or 1.0 ng/mL as antibiotic triggers can cause overtreatment. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
Surgery and sterile inflammation can increase procalcitonin without bacterial infection. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients
Low PCT thresholds in prior surgical populations may have made antibiotic overuse an expected trial-design consequence. — KInetics of Procalcitonin to Reduce Unnecessary aNtibiotic use (KIPRUN): protocol for a multicentre, randomised, superiority trial to compare the efficacy and safety of procalcitonin kinetics-guided and absolute procalcitonin value-guided antibiotic initiation in critically ill patients