Propofol

Uses

How it works

Dosage & preparation

Risks & contraindications

Comparisons

Background

Highlighted claims

• Propofol has no intrinsic analgesic properties and must be combined with an analgesic agent. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol
• In this trial, propofol is dosed at 3 mg/kg IV for induction then titrated in 1 mg/kg increments to maintain a Ramsey Sedation Scale score of 5 or higher. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol
• The combination of propofol and fentanyl is the current standard regimen for procedural sedation and analgesia. — Comparison of remimazolam versus propofol under deep sedation for elderly patients during prostate biopsy: a protocol for a randomised controlled trial
• In a prior ERCP comparative study, the need for airway management due to hypoxia was significantly higher in the propofol group than in the remimazolam group. — Comparison of remimazolam versus propofol under deep sedation for elderly patients during prostate biopsy: a protocol for a randomised controlled trial
• A preliminary institutional study found severe apnoea occurred in 70% of propofol-sedated patients versus 20% of remimazolam-sedated patients. — Comparison of remimazolam versus propofol under deep sedation for elderly patients during prostate biopsy: a protocol for a randomised controlled trial
• Propofol is the dominant sedative-hypnotic for paediatric procedural sedation due to its rapid onset, consistent effect, and complete recovery. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol
• Propofol combined with fentanyl frequently causes hypoxaemia and apnoea, often necessitating rescue interventions such as mask ventilation. — Comparison of remimazolam versus propofol under deep sedation for elderly patients during prostate biopsy: a protocol for a randomised controlled trial
• Ketamine has been studied in combination with propofol in a preparation known as ketofol. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol