PROSPER Trial
Cross-source consensus on PROSPER Trial from 1 sources and 7 claims.
1 sources · 7 claims
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Highlighted claims
- PROSPER is a two-arm, multicentre, parallel-group, single-blind randomised controlled trial comparing TPI plus TAU against TAU alone over 24 weeks. — Preparation for online psychological therapy for depression in people living with and beyond cancer in East Midlands NHS primary and secondary care services in England: protocol for the PROSPER randomised controlled trial
- A total of 160 participants were enrolled, exceeding the pre-specified target of 150. — Preparation for online psychological therapy for depression in people living with and beyond cancer in East Midlands NHS primary and secondary care services in England: protocol for the PROSPER randomised controlled trial
- The primary outcome is change in depression severity measured by the PHQ-9 across four follow-up time points at 4, 8, 12, and 24 weeks post-randomisation. — Preparation for online psychological therapy for depression in people living with and beyond cancer in East Midlands NHS primary and secondary care services in England: protocol for the PROSPER randomised controlled trial
- Analysis follows an intention-to-treat framework using multilevel modelling with participants as level-2 units. — Preparation for online psychological therapy for depression in people living with and beyond cancer in East Midlands NHS primary and secondary care services in England: protocol for the PROSPER randomised controlled trial
- The trial is powered to detect a 3-point difference on the PHQ-9, representing the Minimally Clinically Important Difference. — Preparation for online psychological therapy for depression in people living with and beyond cancer in East Midlands NHS primary and secondary care services in England: protocol for the PROSPER randomised controlled trial
- The pragmatic RCT design, embedded within routine NHS pathways, enhances generalisability and real-world relevance. — Preparation for online psychological therapy for depression in people living with and beyond cancer in East Midlands NHS primary and secondary care services in England: protocol for the PROSPER randomised controlled trial
- The absence of detailed oncology data as baseline variables limits subgroup interpretation but will inform future trial design. — Preparation for online psychological therapy for depression in people living with and beyond cancer in East Midlands NHS primary and secondary care services in England: protocol for the PROSPER randomised controlled trial