Psychotomimetic Effects

How it works

Dosage & preparation

Risks & contraindications

Comparisons

Evidence quality

Highlighted claims

• Psychotomimetic effects are assessed 24 hours after each procedure and include nightmares, nausea, vomiting, fatigue, dizziness, and headache. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol
• The non-inferiority test for the composite psychotomimetic endpoint requires the upper bound of the 95% CI for risk difference to be less than 9%. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol
• The primary limitation of the trial is that sample size is powered for desaturation rather than psychotomimetic events, because desaturation is an objective, immediately life-threatening risk while psychotomimetic effects are subjective and language-dependent. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol
• Observed side effects of ketamine include nightmares, vomiting, diplopia, abnormal behaviour, and dream-like states. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol
• Esketamine is associated with a lower incidence of psychotropic side effects than racemic ketamine while offering greater potency. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol
• The study may not be fully powered to detect modest differences in psychiatric adverse events between esketamine and remifentanil. — Safety and efficacy of esketamine versus remifentanil as adjuncts to propofol sedation in children undergoing haematologic-oncologic procedures in China: a single-centre, randomised, controlled, crossover trial protocol