Regulatory Logic
Cross-source consensus on Regulatory Logic from 1 sources and 5 claims.
1 sources · 5 claims
How it works
Highlighted claims
- The key regulatory logic combines epithelial-mesenchymal antagonism, senescence control, inflammatory signaling, and telomerase-associated immortality. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
- NF-kB is used as a representation of inflammatory signaling in the model. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
- ESE-2 represents epithelial ETS transcription factor activity and represses Snai2. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
- Snai2 represents EMT transcription factor activity that represses epithelial genes and supports mesenchymal identity. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
- p16 and p53 represent senescence-associated tumor suppressive activity, while Rb represses E2F-driven cell-cycle progression. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis