Safety and Eligibility

Risks & contraindications

Evidence quality

Other

Highlighted claims

• Eligible participants are 18–36 months old, stunted or severely stunted, and living in high enteric pathogen burden catchment areas. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• Exclusion criteria include severe acute illness requiring hospitalization, contraindicating metabolic disorders, and current enrolment in other nutrition intervention trials. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• There is no established upper intake limit for amino acids. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• Reported amino acid adverse effects have occurred only at doses 10–30 times higher than the proposed dose and with prolonged use. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials
• Prior neonatal studies used comparable doses and a systematic review found no increased adverse event incidence. — Impact of indispensable amino acid supplementation on gut function in children at high risk of environmental enteropathy: protocol for an international coordinated group of randomised controlled trials