SAVE-O2 AI Trial

Uses

How it works

Background

Evidence quality

Highlighted claims

• SAVE-O2 AI is a multicentre, open-label, parallel-group RCT at four US level 1 trauma and tertiary care hospitals. — Statistical analysis plan for the Strategy to Avoid Excessive Oxygen using Autonomous Oxygen Titration Intervention (SAVE-O2 AI) trial: protocol
• Although the trial is open-label for patients and clinicians, outcome assessments are performed by physicians and statisticians blinded to group allocation. — Statistical analysis plan for the Strategy to Avoid Excessive Oxygen using Autonomous Oxygen Titration Intervention (SAVE-O2 AI) trial: protocol
• Eligible patients must be adults aged 18 or older who can be randomized within 36 hours of hospital arrival and are receiving supplemental oxygen at 1–10 L/min. — Statistical analysis plan for the Strategy to Avoid Excessive Oxygen using Autonomous Oxygen Titration Intervention (SAVE-O2 AI) trial: protocol
• Trial enrollment began May 6, 2024, and the trial is registered at ClinicalTrials.gov as NCT06374225. — Statistical analysis plan for the Strategy to Avoid Excessive Oxygen using Autonomous Oxygen Titration Intervention (SAVE-O2 AI) trial: protocol
• Both the University of Colorado (Clinical Coordinating Centre) and Vanderbilt University Medical Center (Data Coordinating Centre) serve as coordinating centers for the trial. — Statistical analysis plan for the Strategy to Avoid Excessive Oxygen using Autonomous Oxygen Titration Intervention (SAVE-O2 AI) trial: protocol
• No randomized trial of autonomous oxygen titration in non-ventilated patients has previously been conducted in the United States. — Statistical analysis plan for the Strategy to Avoid Excessive Oxygen using Autonomous Oxygen Titration Intervention (SAVE-O2 AI) trial: protocol