SMILE Study

Preparation

Evidence quality

Other

Other

Highlighted claims

• SMILE recruits Ebola virus disease survivors and seronegative close contacts in a 1:2 ratio. — Understanding the pathogenesis of uveitis in Ebola virus disease survivors: an observational cohort and cross-sectional study protocol for clinical, molecular virologic and immunologic characterisation
• Images in SMILE are assessed by two masked central graders, with discrepancies adjudicated by a uveitis or retina subspecialist. — Understanding the pathogenesis of uveitis in Ebola virus disease survivors: an observational cohort and cross-sectional study protocol for clinical, molecular virologic and immunologic characterisation
• The SMILE study is an observational cohort focused on prevalence, clinical spectrum, and risk factors for uveitis. — Understanding the pathogenesis of uveitis in Ebola virus disease survivors: an observational cohort and cross-sectional study protocol for clinical, molecular virologic and immunologic characterisation
• Aim 1 uses multivariate logistic regression to identify independent predictors of uveitis. — Understanding the pathogenesis of uveitis in Ebola virus disease survivors: an observational cohort and cross-sectional study protocol for clinical, molecular virologic and immunologic characterisation
• The SMILE power calculation assumes 10% uveitis prevalence in survivors versus 1% in controls. — Understanding the pathogenesis of uveitis in Ebola virus disease survivors: an observational cohort and cross-sectional study protocol for clinical, molecular virologic and immunologic characterisation
• SMILE uses a comprehensive ophthalmic evaluation that includes visual acuity, intraocular pressure, slit lamp examination, fundus photography, OCT, FFA when indicated, and B-scan ultrasonography when needed. — Understanding the pathogenesis of uveitis in Ebola virus disease survivors: an observational cohort and cross-sectional study protocol for clinical, molecular virologic and immunologic characterisation