Spectral Prognostic Score

How it works

Evidence quality

Highlighted claims

• Modes with disease variance above healthy isotropic variance increase the score, while modes below it decrease the score. — Disease Is a Spectral Perturbation
• The prognostic score is computed from squared patient projections onto disease eigenmodes. — Disease Is a Spectral Perturbation
• The score is Neyman-Pearson optimal only under Gaussian, zero-mean, isotropic-healthy assumptions. — Disease Is a Spectral Perturbation
• For non-isotropic healthy covariance, the optimal statistic requires a generalized eigenvalue problem involving both healthy and disease Hamiltonians. — Disease Is a Spectral Perturbation