Spontaneous Immortalization

How it works

Evidence quality

Highlighted claims

• Spontaneous immortalization of human epithelial cells proceeds through senescence, EMT-associated senescence escape, and a mesenchymal stem-like tumorigenic phenotype. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The nine-node module is sufficient in the model to reproduce the progression from epithelial to senescent to mesenchymal stem-like states. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The model recapitulates the observed time order of spontaneous immortalization phenotypes. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis
• The modeled spontaneous immortalization sequence is linked to inflammation-induced EMT and proposed to parallel phenotype enrichment during carcinoma progression in vivo. — Dynamic network and epigenetic landscape model of a regulatory core underlying spontaneous immortalization and epithelial carcinogenesis