SSRIs
Cross-source consensus on SSRIs from 2 sources and 9 claims.
2 sources · 9 claims
How it works
Risks & contraindications
Comparisons
Background
Evidence quality
Highlighted claims
- SSRIs block serotonin reuptake at the synapse, causing the receiving cell to stop registering the serotonin signal. — Depression Has Nothing to Do With Your Brain
- SSRIs work by preventing reabsorption of serotonin in the brain to theoretically increase its availability. — Anxiety and Depression: The Gut Microbiome Connection
- SSRIs carry serious side effects including sexual dysfunction, emotional blunting, worsened depression, and dependency. — Depression Has Nothing to Do With Your Brain
- SSRIs decrease diversity of the gut microbiome, reducing its capacity to produce neurotransmitters and B vitamins. — Anxiety and Depression: The Gut Microbiome Connection
- SSRIs increase gut inflammation, worsening the underlying condition that drove depression. — Anxiety and Depression: The Gut Microbiome Connection
- SSRIs create a self-reinforcing loop in which microbiome damage worsens serotonin production, escalating perceived need for the drug. — Anxiety and Depression: The Gut Microbiome Connection
- SSRIs perform at or near placebo level in clinical trials. — Depression Has Nothing to Do With Your Brain
- The conventional pharmacological approach to depression deepens the gut-depression loop rather than breaking it. — Anxiety and Depression: The Gut Microbiome Connection
- The FDA ban on tryptophan supplements in 1990 coincided with Prozac's rise and was lifted after Prozac's patent expired. — Depression Has Nothing to Do With Your Brain