St. John's Wort
Cross-source consensus on St. John's Wort from 2 sources and 7 claims.
2 sources · 7 claims
How it works
Benefits
Interactions
Comparisons
Evidence quality
Highlighted claims
- St. John's Wort is a potent inducer of cytochrome P450 enzymes (CYP3A4), causing many co-administered medications to be metabolized faster or, in some cases, to reach toxic concentrations. — 6 Herbs Toxic for Your Liver
- St. John's Wort is highly effective for depression and anxiety when the user is not taking pharmaceutical medications. — 6 Herbs Toxic for Your Liver
- Psychiatric drugs are particularly problematic in combination with St. John's Wort and the combination requires medical supervision. — 6 Herbs Toxic for Your Liver
- St. John's Wort acts on serotonin, dopamine, inflammation, and cortisol — multiple mechanisms that SSRIs do not. — Depression Has Nothing to Do With Your Brain
- St. John's Wort outperforms placebo more consistently than SSRIs without the severe side effect profile. — Depression Has Nothing to Do With Your Brain
- Medical warnings against combining St. John's Wort with psychiatric drugs implicitly confirm its pharmacological activity. — Depression Has Nothing to Do With Your Brain
- Negative research findings on St. John's Wort may reflect financial bias, given that it competes directly with the multi-billion-dollar antidepressant and anti-anxiety pharmaceutical market. — 6 Herbs Toxic for Your Liver