Stress Hyperglycaemia

How it works

Highlighted claims

• Elevated counter-regulatory hormones and pro-inflammatory cytokines stimulate gluconeogenesis and glycogenolysis in critical illness, producing stress hyperglycaemia even in patients without pre-existing diabetes. — Predictive value of stress hyperglycaemia ratio and haemoglobin glycation index for mortality risks in critically ill patients: a comparative retrospective analysis of the MIMIC-IV database using machine learning-based predictive modelling
• Counter-regulatory hormone release drives gluconeogenesis and glycogenolysis, leading to elevated admission blood glucose during critical illness. — Predictive value of stress hyperglycaemia ratio and haemoglobin glycation index for mortality risks in critically ill patients: a comparative retrospective analysis of the MIMIC-IV database using machine learning-based predictive modelling
• The pathophysiology linking SHR elevation to poor outcomes centres on activation of the HPA axis and the sympathetic adrenal system in response to severe physiological stress. — Predictive value of stress hyperglycaemia ratio and haemoglobin glycation index for mortality risks in critically ill patients: a comparative retrospective analysis of the MIMIC-IV database using machine learning-based predictive modelling
• Acute glycaemic elevation and fluctuations directly impair vascular function, induce endothelial dysfunction, and increase endothelial apoptosis, worsening prognosis through compounding organ damage. — Predictive value of stress hyperglycaemia ratio and haemoglobin glycation index for mortality risks in critically ill patients: a comparative retrospective analysis of the MIMIC-IV database using machine learning-based predictive modelling