Surgical Antimicrobial Prophylaxis

Dosage & preparation

Preparation

Risks & contraindications

Evidence quality

Other

Highlighted claims

• Surgical antimicrobial prophylaxis is antibiotic administration before skin incision to reduce surgical infection risk. — Multicentre, adaptive, double-blind, three-arm, placebo-controlled, non-inferiority trial examining antimicrobial prophylaxis duration in cardiac surgery (CALIPSO): trial protocol
• All trial participants receive standard intraoperative antimicrobial prophylaxis. — Multicentre, adaptive, double-blind, three-arm, placebo-controlled, non-inferiority trial examining antimicrobial prophylaxis duration in cardiac surgery (CALIPSO): trial protocol
• The benefit of continuing antibiotics after wound closure in cardiac surgery remains uncertain. — Multicentre, adaptive, double-blind, three-arm, placebo-controlled, non-inferiority trial examining antimicrobial prophylaxis duration in cardiac surgery (CALIPSO): trial protocol
• The Australian Therapeutic Guidelines recommend preoperative intravenous cefazolin within 60 minutes before skin incision and intraoperative redosing every 3-4 hours for prolonged operations. — Multicentre, adaptive, double-blind, three-arm, placebo-controlled, non-inferiority trial examining antimicrobial prophylaxis duration in cardiac surgery (CALIPSO): trial protocol
• Longer antimicrobial exposure may increase harms including antimicrobial resistance, C. difficile infection, microbiome disruption, acute kidney injury, and costs. — Multicentre, adaptive, double-blind, three-arm, placebo-controlled, non-inferiority trial examining antimicrobial prophylaxis duration in cardiac surgery (CALIPSO): trial protocol