Trial Analysis and Oversight

Risks & contraindications

Evidence quality

Other

Highlighted claims

• The target sample is 432 participants, with 144 participants per arm. — NeuroMusic: protocol for a randomised-controlled trial of keyboard and singing music training programmes for older adults with mild cognitive impairment
• The primary analysis uses intention-to-treat principles and linear mixed models to test treatment-by-time interactions on RAVLT Trial 7. — NeuroMusic: protocol for a randomised-controlled trial of keyboard and singing music training programmes for older adults with mild cognitive impairment
• A blinded interim analysis in April 2025 confirmed no need to change the sample size. — NeuroMusic: protocol for a randomised-controlled trial of keyboard and singing music training programmes for older adults with mild cognitive impairment
• Assessment staff and the trial statistician remain blinded to group allocation. — NeuroMusic: protocol for a randomised-controlled trial of keyboard and singing music training programmes for older adults with mild cognitive impairment
• Data are stored in REDCap with restricted access and coded participant identifiers. — NeuroMusic: protocol for a randomised-controlled trial of keyboard and singing music training programmes for older adults with mild cognitive impairment
• A Data Safety Monitoring Board was not required because the interventions were considered minimal risk. — NeuroMusic: protocol for a randomised-controlled trial of keyboard and singing music training programmes for older adults with mild cognitive impairment