Trial Assessment and Analysis

Evidence quality

Other

Other

Highlighted claims

• The trial has baseline, end-of-CRT and six-month post-CRT research visits. — Randomised controlled trial on the efficacy of adding cognitive remediation therapy to methylphenidate in adult patients with attention deficit hyperactivity disorder and addictive disorders (META): CRT in ADHD and addiction – META study protocol
• The primary analysis compares functional improvement between groups using a mixed logistic regression model. — Randomised controlled trial on the efficacy of adding cognitive remediation therapy to methylphenidate in adult patients with attention deficit hyperactivity disorder and addictive disorders (META): CRT in ADHD and addiction – META study protocol
• Missing primary outcome data will be treated as no functional improvement in worst-case imputation. — Randomised controlled trial on the efficacy of adding cognitive remediation therapy to methylphenidate in adult patients with attention deficit hyperactivity disorder and addictive disorders (META): CRT in ADHD and addiction – META study protocol
• The neuropsychological battery is intentionally limited to support feasibility and acceptability in routine clinical settings. — Randomised controlled trial on the efficacy of adding cognitive remediation therapy to methylphenidate in adult patients with attention deficit hyperactivity disorder and addictive disorders (META): CRT in ADHD and addiction – META study protocol
• All analyses follow the intention-to-treat principle, with possible complementary per-protocol analyses. — Randomised controlled trial on the efficacy of adding cognitive remediation therapy to methylphenidate in adult patients with attention deficit hyperactivity disorder and addictive disorders (META): CRT in ADHD and addiction – META study protocol