Viral Genomic Sequencing

Cross-source consensus on Viral Genomic Sequencing from 1 sources and 5 claims.

1 sources · 5 claims

Uses

The study includes genomic surveillance to detect RSV variants and assess whether lineages or mutations reduce protection. — Real-world effectiveness of perinatal RSV immunoprophylaxis: protocol for a test-negative case–control study
Laboratory personnel interpreting tests will be blinded to participants' RSV monoclonal antibody or maternal vaccine exposure status. — Real-world effectiveness of perinatal RSV immunoprophylaxis: protocol for a test-negative case–control study
Respiratory samples will be screened by RT-qPCR for human RNase P, and only samples with cycle threshold values of 35 or lower will be included. — Real-world effectiveness of perinatal RSV immunoprophylaxis: protocol for a test-negative case–control study
Sequencing reads will be aligned to RSV-A and RSV-B reference genomes, and lineages will be characterized using Nextstrain and maximum-likelihood phylogeny. — Real-world effectiveness of perinatal RSV immunoprophylaxis: protocol for a test-negative case–control study
The study will test whether breakthrough infections are disproportionately associated with particular RSV viral groups. — Real-world effectiveness of perinatal RSV immunoprophylaxis: protocol for a test-negative case–control study