WAVE Trial

Comparisons

Background

Evidence quality

Where it comes from

Highlighted claims

• WAVE is a prospective multicentre randomised controlled non-inferiority trial comparing thermal ablation with laparoscopic adrenalectomy. — Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial
• The trial tests non-inferiority of thermal ablation first for biochemical cure and then for clinical cure using PASO criteria. — Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial
• The trial uses an open-label PROBE design with blinded endpoint determination. — Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial
• The trial is coordinated by Queen Mary University of London and includes six NHS centres. — Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial
• Recruitment began in September 2022 and the expected overall study completion is mid-2027. — Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial