Weight-Loss Maintenance

Uses

How it works

Benefits

Risks & contraindications

Comparisons

Highlighted claims

• The trial found that orforglipron maintained significantly more prior weight loss than placebo in both cohorts. — Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
• Among plateau participants, maintenance was 75% versus 49% after tirzepatide and 79% versus 38% after semaglutide. — Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
• The study focuses on maintaining weight loss after weight reduction in people with overweight or obesity. — Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial
• The cited literature frames losing weight and maintaining weight loss as biologically different challenges. — Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial
• Switching to orforglipron maintained nearly all semaglutide-associated weight loss and most tirzepatide-associated weight loss. — Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
• The cited reference list emphasizes that maintaining weight loss can be difficult after pharmacological treatment stops. — Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial
• Cohort 1 participants assigned only to orforglipron regained about 5 percentage points or about 5 kg from ATTAIN-MAINTAIN baseline by week 52. — Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
• Cohort 2 participants assigned only to orforglipron regained about 1 percentage point or about 1 kg from ATTAIN-MAINTAIN baseline by week 52. — Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial
• The cited adipose tissue literature includes mechanisms for weight regain and epigenetic memory after obesity. — Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial